Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGTArticle Published on 2021-09-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Arabidopsis thaliana Cell cells cellular database dataset determine DNA repair Drosophila melanogaster enzyme functional Homo sapien hub protein human protein Identified Interaction its target proteins metabolism molecular network Mus network O-GlcNAc OGT OGT interactome Protein Protein–protein interaction protein–protein interactions Rattus Regulation Repository RNA significant enrichment Transcription translational [DOI] 10.3390/ijms22179620 PMC 바로가기 [Article Type] Article
Identification of Causal Genes of COVID-19 Using the SMR MethodGenetics Published on 2021-07-052022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Analysis applied cardiac failure cardiac muscle Causal complications of COVID-19 COVID-19 COVID-19 pathogenesis COVID-19 patients eQTL FIVE genetic cause GWAS identification infected with SARS-CoV-2 instrumental variable involved Italian patient knowledge lung mechanism myocardial damage Neurological disease nine observational study occur OGT PANO1 potential molecular PPA2 regulated Research risk risk factor SCD SMR SNP Spanish UQCRH with COVID-19 [DOI] 10.3389/fgene.2021.690349 PMC 바로가기 [Article Type] Genetics